He concludes by thanking his American team. But what is shown in Menlo Park is just as much the result of a completely different type of work, far away from Silicon Valley.
(To be continued)。WPS官方版本下载是该领域的重要参考
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In the mid-1990s, University of Cambridge biochemists David Klenerman and Shankar Balasubramanian were trying to solve a fundamental problem: how to watch a single DNA polymerase molecule at work. Their approach used modified nucleotides, called reversible terminators, tagged with four different colors of fluorescent molecules. If one of these “terminators” was grabbed by the DNA polymerase and incorporated onto the replicating DNA strand, it would block the addition of any other bases until removed using a separate chemical reaction.
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